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June 2009

Pfizer's Sutent fails in colon cancer, trial halted (Reuters)

NEW YORK (Reuters) –
Pfizer Inc said a late stage trial testing its cancer drug Sutent in advanced colon cancer was discontinued after it was deemed to be no more effective than standard chemotherapy.

An independent Data Monitoring Committee found that adding Sutent to a chemotherapy regimen as an initial treatment for colon cancer that has spread would be unable to show a statistically significant improvement in progression-free survival compared with the chemotherapy alone, Pfizer said.

The world's largest drugmaker said no new safety issues were identified with Sutent, known chemically as sunitinib.

The setback comes just days after Sutent proved effective against a rare form of pancreatic cancer in another Phase III trial.

"We are disappointed with this result, but trial successes and failures are an integral part of cancer drug development and contribute to a growing body of knowledge on improving patient care," Mace Rothenberg, head of clinical development and medical affairs for Pfizer's oncology unit, said in a statement.

Sutent is currently approved to treat advanced kidney cancer and gastrointestinal stromal tumor, a cancer of the digestive system. The disappointment in metastatic colon cancer does not impact the approved uses of the drug.

Pfizer said it would continue to study Sutent in late-stage trials as a potential treatment for various other types of cancer and work to develop other colon cancer treatments.

Its shares were off just 1 cent to $14.98 in extended trading.

(Reporting by Bill Berkrot; Editing by Tim Dobbyn)

Jaguars trade Northcutt to Lions for Alexander (AP)

JACKSONVILLE, Fla. – The Jacksonville Jaguars have traded receiver Dennis Northcutt to the Detroit Lions for safety Gerald Alexander.
The deal was finalized Tuesday after both players passed physicals.
Northcutt gives the Lions a veteran receiver opposite rising star Calvin Johnson.
Alexander, a second-round pick in 2007, gives Jacksonville depth in the secondary. He started 16 games as a rookie, but missed most of last year following a neck injury.
Northcutt, who has 364 receptions for 4,584 yards and 17 touchdowns, has been projected to start this season. But Jacksonville's three rookie receivers were impressive enough during offseason drills that Northcutt became expendable.

Fans gather for Apollo Theater's Jackson memorial (AP)

NEW YORK – Hundreds of Michael Jackson fans circled the block around Harlem's famed Apollo Theater Tuesday for a public tribute to the pop star, some spontaneously singing their favorite songs and dancing in the street.
"I thought that in my time I'd have the opportunity to see him in concert," said Victoria Campomames, who did a brief moonwalk on the sidewalk as "Rock With You" played from a nearby store. "This is about the closest I'm gonna get."
Campomames, wearing a Jackson-style spangled black jacket, fedora and white gloves, took the day off from her job at a grocery store in Morrisville, Vt., for the all-day tribute to Jackson at the fabled venue that helped make him a star.
Thousands were expected to pay their respects at the theater, which planned to let them in 600 at a time to listen to his music, watch a video tribute and leave flowers and memorabilia.
The event was set to start at 2 p.m., but many people were already waiting Tuesday morning, dancing as they lined up with T-shirts, posters, album covers and other mementoes.
Ebony Johnson, 19, arrived at midnight to secure a spot near the front of the line, clutching a Jackson scrapbook she started when she was 14. An image of the star was tattooed on her left arm. She said she got the tattoo last month in anticipation of his planned comeback shows in London.
"I love him so much — I can't explain that in words," she said. "I felt like Michael was my family."
Fans wrote messages on a wall of remembrance outside the 125th street theater. "God bless and be with you M. Jackson," wrote one fan. "We all share your grief. Love always," read a message to his family.
Fans began converging on the Apollo soon after Jackson died Thursday in Los Angeles. It has continued to serve as an impromptu memorial site in the days since.
The pop icon's ties to the theater go back to 1967, when The Jackson 5 won the Apollo's Amateur Night contest. The appearance is credited with helping to launch the brother act's career, which later propelled Jackson to solo stardom.
Jackson last appeared at the Apollo in 2002, invited by former President Bill Clinton for a Democratic National Committee fundraiser.
Tuesday's salute was to begin with a eulogy by the Rev. Al Sharpton. A moment of silence was planned for 5:26 p.m., the time East Coast fans learned that Jackson had died.
The Apollo also played a role in remembrances for James Brown after his death in 2006, hosting a public viewing of the "Godfather of Soul" for thousands of fans.

Photo Puzzles

Site

A sample of notable puzzle authors includes Sam Loyd, Henry Dudeney, Boris Kordemsky and, more recently, David J. Bodycombe, Will Shortz and Martin Gardner.

The Rubik's Cube and other magic polyhedrons are toys based on puzzles that can be stimulating toys for kids and are a recreational activity for adults. Puzzles can be used to hide or obscure objects. A good example is a puzzle box used to hide jewelry.

Treasury OKs 3 firms for mortgage relief program (AP)

WASHINGTON – The Treasury Department said Tuesday that it has approved three more firms for its mortgage relief program.
The new approvals brought the number of companies participating in the mortgage effort to 23 with the total amount authorized for all of the firms rising to $17.98 billion out of a maximum of $50 billion the government has said it could spend on this program.
The money is being provided to support the government's effort to combat a wave of mortgage foreclosures by giving incentives for homeowners to modify their existing mortgages.
The new approvals for this program included National City Bank of Miamisburg, Ohio; Technology Credit Union of San Jose, Calif., and Citizens First Wholesale Mortgage Co. of The Villages, Fla.
The government also confirmed Tuesday that Hartford Financial Services Group Inc. had become the first among a group of six major life insurers to get assistance from the government's $700 billion financial rescue fund.
Hartford won approval in May from the government to gain access to the bailout program. The six companies had sought federal aid in the wake of major investment losses resulting from the financial market turmoil of last fall.
Hartford announced the federal support on Friday, but under the rules that govern the bailout program, Treasury has two business days to acknowledge transactions involving the fund.
The $3.4 billion in support provided to Hartford was by far the largest award on Tuesday. In addition, a group of 15 smaller banks received $226 million from the rescue fund bringing the total in support to $203.2 billion.
Last week, Treasury established a process for pricing billions of dollars worth of warrants that banks much repurchase from the government to exit the bailout program. Treasury said that the banks can make the first offer of a purchase price and then Treasury will decide whether to accept that offer or make a counteroffer.

Promoter: Tribute shows for Jackson likely (AP)

LONDON – The promoter who booked Michael Jackson for a sold-out comeback tour says a tribute show based on his canceled concerts is likely.
Randy Phillips, chief executive of promoter AEG Live, told Britain's Sky News television on Tuesday that the "world needs to see" the production Jackson had been working on.
He says members of the Jackson family, and other world music stars, could take part in a tribute show using routines and sets already created for the scrapped tour.
Phillips says he believes Jackson's comeback would have been one of the best arena shows ever produced. He says a video of Jackson's rehearsals for the tour does exist.
He says Jackson said he believed he was ready for the 50 sold-out performances at London's O2 arena.

Nesting Dolls

Matryoshkas date from 1890, and are said to have been inspired by souvenir dolls from Japan. However, the concept of nested objects was familiar in Russia, having been applied to carved wooden apples and Easter eggs; the first Fabergé egg, in 1885, had a nesting of egg, yolk, hen, and chick.

Modern artists create many new styles of nesting dolls. The most common themes feature animal collections, portraits and caricatures of famous politicians, musicians and popular movie stars. Matryoshka dolls that feature communist leaders of Russia became very popular among Russian people in the early 90's, after the collapse of the Soviet Union. Today, many talented Russian artists specialize in painting themed matryoshka dolls that feature specific categories of subjects, people or nature.

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Man had boss killed to save job - Spanish police (Reuters)

MADRID (Reuters) –
Spanish police have arrested a man whom they suspect hired a contract killer to murder his boss in a desperate bid to avoid being laid off, newspaper El Pais reported on Tuesday.

The head of audiovisual services at the Barcelona International Convention Centre contracted a Colombian man who shot and killed the director of the convention centre on Feb 9, according to police.

The director had planned to lay off the arrested man as part of a restructuring project, police said.

In fear of losing his job, the head of services, through his sister, contracted a team of six Colombians who planned and carried out the killing, El Pais reported.

Police have also detained the sister and six Colombians.

The shooting marks one of the most extreme actions by Spaniards who fear losing jobs, homes and businesses during a recession in which unemployment is rising faster than in any other developed country.

Other cases include an indebted Spanish builder who kidnapped his bank manager at gunpoint and the head of a construction firm who threatened to set himself on fire unless debts he was owed were paid.

(Reporting by Andrew Hay; Editing by Matthew Jones)

Sales Tax Consulting

Sales Tax Consulting

Periodic review of procedures relating to Sales & Use Tax data gathering and retention so that proper supporting documentation, including exemption and resale certificates, are available in the event of a State audit.

A related type of tax is the value-added tax or VAT. It is a system in which all businesses remit taxes on their sales but they are also refunded the amount of VAT remitted by their suppliers. In addition to avoiding cascading, under VAT there is no need for government to determine which sales are taxable and which are not, since all sales--retail, wholesale and intermediate--are taxed.

China's internet porn filter -- no Depp please (Reuters)

BEIJING (Reuters) –
What do Johnny Depp, Garfield, Paris Hilton and roast pork have in common? In China, the answer is that a new government-mandated Internet filter rates some pictures of all four of them as bad for your moral health.

Beijing has ordered all personal computers sold in China from July 1 to be preinstalled with the Green Dam software, which it says is designed to block pornographic and violent images, and which critics fear will be used to extend censorship.

But a trial of the programme, which is available online for free download (http://www.skycn.com/soft/46657.html), suggested

its filters may be of limited use to worried parents.

When the software is installed, and an image scanner activated, it blocks even harmless images of a film poster for cartoon cat Garfield, dishes of flesh-colour cooked pork and on one search engine a close-up of film star Johnny Depp's face.

With the image filter off, even though searches with words like "nude" are blocked, a hunt for adult websites throws up links to soft and hardcore pornography sites including one with a video of full penetrative sex playing on its front page.

Green Dam has not detailed how it scans images for obscene content, but computer experts have said it likely uses colour and form recognition to zoom in on potential expanses of naked flesh.

Programme settings allow users to chose how tightly they want images scanned. When too much skin is detected, Green Dam closes all internet browsers with no warning, sometimes flashing up a notice that the viewer is looking at "harmful" content.

But the interpretation of obscene is apparently generous enough to include the orange hue of Garfield's fur and, on the highest security settings, prevent viewers clicking through to any illustrated story on one English language news website.

A programme to scan written content appears less sensitive, with a string of explicit words typed into a word document triggering no response, although some users have complained in online forums of shut-downs similar to those of web browsers.

SEX OR POLITICS?

The software also allows users to choose what they want to filter for, and besides adult websites and violence, categories include "gay" and "illegal activities."

Gay and health activists fear the blanket ban on "gay content," in a country where homosexuality is not criminalised, could damage projects including sexual health and AIDS education.

And government critics worry the "illegal activities" section will cover political and social activities Beijing objects to, tightening access to non-approved information, already filtered by censors and a firewall.

Another setting allows Green Dam to take regular snapshots of a user's screen and store them for up to two weeks -- ostensibly so parents can monitor computer use by minors.

But it could also potentially leave security officials a track of computer use by a suspected dissident, or be a gift to fraudsters hunting online bank details and private information.

Researchers in the U.S. have already said they are concerned Green Dam leaves users vulnerable to malicious sites that might steal personal data or install code on the personal computer.

Western governments and trade groups have also asked China to reconsider, based on concerns ranging from cyber-security and performance of the software to Internet freedoms.

"People say the software is not very stable and has many technological problems," said Joerg Wuttke, the president of the European Union Chamber of Commerce in China, which has dubbed the introduction of Green Dam "hasty."

China's foreign ministry on Tuesday declined to respond to criticisms of the software.

(Additional reporting by Maxim Duncan, Kirby Chien and Alan Wheatley; Editing by Jerry Norton)